V2 av_gene
255,731 rows · 29 columns
| GENEID | TUMOURID | PATIENTID | GENE_DESC | GENE | COUNT_TESTS | COUNT_RESULTS | COUNT_DATE | ALL_TESTSTATUSES | OVERALL_TS | NO_OF_AB_GATS | DNASEQ_GAT | METHYL_GAT | EXP_GAT | COPYNO_GAT | FUS_TRANS_GAT | ABNORMAL_GAT | NO_OF_SEQ_VARS | ALL_SEQ_VARS | SEQ_VAR | DATE_OVERALL_TS | BEST_DATE_SOURCE_OVERALL_TS | MIN_DATE | MAX_DATE | ALL_PRO_IMPS | NO_OF_PRO_IMPS | PRO_IMP | METHODS | LAB_NAME |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 100079979 | 11958209 | 100038147 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.34G>T | c.34G>T | 2016-11-18 | 1)authoriseddate | 2016-11-07 | 2016-11-18 | p.(Gly12Cys) | 1 | p.(Gly12Cys) | Sequencing, Next Generation (NGS) | Cambridge (molecular lab) |
| 100079980 | 11708783 | 100038148 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.35G>C | c.35G>C | 2017-12-05 | 3)receiveddate | 2017-12-07 | 2017-12-05 | p.(Gly12Ala) | 1 | p.(Gly12Ala) | Mass Spectrometry Genotyping / MALDI-TOF | Royal Marsden (molecular lab) |
| 100079981 | 10310869 | 100038149 | KRAS | 47 | 1 | 1 | 1 | e:failed | e:failed | 0 | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-05-23 | 1)authoriseddate | 2017-05-12 | 2017-05-23 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100079982 | 10706423 | 100038150 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-12-28 | 1)authoriseddate | 2018-10-12 | 2018-12-28 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100079983 | 11893925 | 100038151 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-07-29 | 1)authoriseddate | 2017-08-24 | 2017-09-12 | null | 0 | null | Pyrosequencing | Royal Marsden (molecular lab) |
| 100079984 | 10486768 | 100038152 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-12-01 | 1)authoriseddate | 2017-12-06 | 2017-12-01 | null | 0 | null | Unknown | Sheffield (molecular lab) |
| 100079985 | 11117960 | 100038153 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-09-24 | 1)authoriseddate | 2019-09-24 | 2019-09-28 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100079986 | 10310160 | 100038154 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-01-01 | 3)receiveddate | 2018-01-06 | 2018-01-01 | null | 0 | null | Sequencing, Next Generation (NGS) | Leeds (molecular lab) |
| 100079987 | 10479079 | 100038155 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-07-11 | 1)authoriseddate | 2019-07-15 | 2019-07-11 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100079988 | 11618108 | 100038156 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-03-01 | 3)receiveddate | 2017-03-20 | 2017-03-01 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100079990 | 10246338 | 100038158 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-02-02 | 1)authoriseddate | 2017-02-12 | 2017-02-02 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100079991 | 10927816 | 100038159 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.35G>A | c.35G>A | 2018-10-11 | 1)authoriseddate | 2018-11-08 | 2019-01-17 | p.(Gly12Asp) | 1 | p.(Gly12Asp) | Pyrosequencing,Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100079993 | 10821247 | 100038161 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-02-04 | 3)receiveddate | 2019-03-04 | 2019-02-04 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100079994 | 10306426 | 100038162 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-10-12 | 3)receiveddate | 2019-10-06 | 2019-10-12 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100079995 | 10337590 | 100038163 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-02-15 | 1)authoriseddate | 2019-03-12 | 2019-02-15 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100079996 | 11573083 | 100038164 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-01-07 | 1)authoriseddate | 2017-02-05 | 2017-01-07 | null | 0 | null | Unknown | Birmingham (molecular lab) |
| 100079997 | 11224211 | 100038165 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-11-08 | 1)authoriseddate | 2016-11-03 | 2016-11-08 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100079998 | 10746286 | 100038166 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-08-24 | 3)receiveddate | 2019-09-22 | 2019-08-24 | null | 0 | null | Pyrosequencing | Royal Marsden (molecular lab) |
| 100079999 | 11112444 | 100038167 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-09-13 | 1)authoriseddate | 2017-07-17 | 2017-09-13 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100080000 | 10542670 | 100038168 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-02-03 | 1)authoriseddate | 2017-01-26 | 2017-02-03 | null | 0 | null | Pyrosequencing | Royal Marsden (molecular lab) |
| 100080001 | 11913944 | 100038169 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.35G>A | c.35G>A | 2016-02-25 | 1)authoriseddate | 2016-02-26 | 2016-02-25 | p.(Gly12Asp) | 1 | p.(Gly12Asp) | Pyrosequencing | Birmingham (molecular lab) |
| 100080002 | 11518830 | 100038170 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-10-19 | 1)authoriseddate | 2016-10-19 | 2016-10-19 | null | 0 | null | Pyrosequencing | Royal Marsden (molecular lab) |
| 100080003 | 10135210 | 100038171 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.34G>T | c.34G>T | 2019-09-26 | 1)authoriseddate | 2019-10-11 | 2019-09-26 | p.(Gly12Cys) | 1 | p.(Gly12Cys) | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080004 | 11593851 | 100038172 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-10-25 | 1)authoriseddate | 2019-10-05 | 2019-10-25 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080005 | 10566044 | 100038173 | KRAS | 47 | 1 | 1 | 1 | e:failed | e:failed | 0 | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-07-25 | 1)authoriseddate | 2019-08-21 | 2019-07-25 | null | 0 | null | Pyrosequencing,Roche COBAS,Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100080006 | 10232309 | 100038174 | KRAS | 47 | 1 | 1 | 1 | e:failed | e:failed | 0 | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-12-16 | 1)authoriseddate | 2018-12-21 | 2018-12-16 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100080007 | 10716655 | 100038175 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-05-11 | 1)authoriseddate | 2016-04-27 | 2016-05-11 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080009 | 10618660 | 100038177 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.35G>A | c.35G>A | 2016-08-20 | 1)authoriseddate | 2016-08-19 | 2016-08-28 | p.(Gly12Asp) | 1 | p.(Gly12Asp) | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100080010 | 10305774 | 100038178 | KRAS | 47 | 1 | 2 | 1 | a:abnormal,e:failed | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.34G>T | c.34G>T | 2018-06-27 | 1)authoriseddate | 2018-03-19 | 2018-06-27 | p.(Gly12Cys) | 1 | p.(Gly12Cys) | Pyrosequencing,Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100080011 | 10801853 | 100038179 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.35G>T | c.35G>T | 2018-08-16 | 1)authoriseddate | 2018-09-14 | 2018-08-16 | p.(Gly12Val) | 1 | p.(Gly12Val) | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080012 | 11676969 | 100038180 | KRAS | 47 | 1 | 2 | 1 | e:failed,e:failed | e:failed | 0 | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-04-28 | 1)authoriseddate | 2016-03-20 | 2016-04-28 | null | 0 | null | Unknown | Bristol (molecular lab) |
| 100080013 | 11262130 | 100038181 | KRAS | 47 | 1 | 2 | 1 | e:failed,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-05-22 | 1)authoriseddate | 2019-05-11 | 2019-05-22 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080014 | 11841834 | 100038182 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-10-23 | 1)authoriseddate | 2017-09-02 | 2017-10-23 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100080015 | 11467988 | 100038183 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-06-22 | 1)authoriseddate | 2018-07-15 | 2018-06-22 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080016 | 11477294 | 100038184 | KRAS | 47 | 1 | 2 | 1 | b:normal,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-09-10 | 1)authoriseddate | 2018-09-02 | 2018-09-10 | null | 0 | null | Sequencing, Next Generation (NGS) | Bristol (molecular lab) |
| 100080017 | 11026884 | 100038185 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-09-21 | 1)authoriseddate | 2019-09-05 | 2019-09-21 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080018 | 10775501 | 100038186 | KRAS | 47 | 1 | 1 | 1 | e:failed | e:failed | 0 | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-01-27 | 1)authoriseddate | 2017-02-10 | 2017-10-12 | null | 0 | null | Immunochemistry | Birmingham (molecular lab) |
| 100080019 | 11020841 | 100038187 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-06-30 | 1)authoriseddate | 2019-06-26 | 2019-06-30 | null | 0 | null | Pyrosequencing | Sheffield (molecular lab) |
| 100080020 | 10994397 | 100038188 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-12-26 | 1)authoriseddate | 2019-12-02 | 2019-12-26 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100080021 | 11393148 | 100038189 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-11-19 | 1)authoriseddate | 2017-12-16 | 2017-11-19 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 100080022 | 10613204 | 100038190 | KRAS | 47 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.35G>C | c.35G>C | 2019-01-25 | 3)receiveddate | 2019-01-27 | 2019-01-25 | p.(Gly12Ala) | 1 | p.(Gly12Ala) | Unknown | Birmingham (molecular lab) |
| 100080023 | 10471619 | 100038191 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-03-10 | 1)authoriseddate | 2017-04-07 | 2017-03-10 | null | 0 | null | Sequencing, Next Generation (NGS) | Exeter (molecular lab) |
| 100080024 | 11153058 | 100038192 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-10-23 | 1)authoriseddate | 2016-11-17 | 2016-10-23 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |
| 100080025 | 11506295 | 100038193 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-02-07 | 1)authoriseddate | 2019-03-09 | 2019-02-07 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Royal Marsden (molecular lab) |
| 100080026 | 11270262 | 100038194 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-07-17 | 1)authoriseddate | 2018-08-14 | 2018-07-17 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100080027 | 10543537 | 100038195 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-09-12 | 1)authoriseddate | 2019-09-19 | 2019-09-12 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100080028 | 10410156 | 100038196 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-12-20 | 1)authoriseddate | 2019-12-01 | 2019-12-20 | null | 0 | null | Pyrosequencing | Royal Marsden (molecular lab) |
| 100080029 | 11178432 | 100038197 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-08-18 | 3)receiveddate | 2018-07-31 | 2018-08-18 | null | 0 | null | Sequencing, Dideoxy/Sanger | Royal Marsden (molecular lab) |
| 100080030 | 10098459 | 100038198 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-08-25 | 1)authoriseddate | 2016-09-03 | 2016-08-25 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 100080031 | 10475075 | 100038199 | KRAS | 47 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-11-01 | 1)authoriseddate | 2016-11-13 | 2016-11-01 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Newcastle (molecular lab) |