V2 av_gene
255,731 rows · 29 columns
| GENEID | TUMOURID | PATIENTID | GENE_DESC | GENE | COUNT_TESTS | COUNT_RESULTS | COUNT_DATE | ALL_TESTSTATUSES | OVERALL_TS | NO_OF_AB_GATS | DNASEQ_GAT | METHYL_GAT | EXP_GAT | COPYNO_GAT | FUS_TRANS_GAT | ABNORMAL_GAT | NO_OF_SEQ_VARS | ALL_SEQ_VARS | SEQ_VAR | DATE_OVERALL_TS | BEST_DATE_SOURCE_OVERALL_TS | MIN_DATE | MAX_DATE | ALL_PRO_IMPS | NO_OF_PRO_IMPS | PRO_IMP | METHODS | LAB_NAME |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 240005703 | 10225592 | 240000264 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-11-01 | 1)authoriseddate | 2018-11-25 | 2018-11-01 | null | 0 | null | SSCP | Royal Marsden (molecular lab) |
| 240005704 | 10233485 | 240000265 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-07-17 | 1)authoriseddate | 2017-08-08 | 2017-07-17 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005705 | 10079339 | 240000268 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-12-27 | 1)authoriseddate | 2016-12-31 | 2017-03-01 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005706 | 10629553 | 240000273 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1142_1144delp.(Glu381del) | c.1142_1144delp.(Glu381del) | 2018-12-06 | 1)authoriseddate | 2018-11-16 | 2018-12-06 | p.Trp557_Glu561del | 1 | p.Trp557_Glu561del | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005713 | 10353448 | 240000288 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2019-04-15 | 1)authoriseddate | 2019-03-06 | 2019-04-15 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005716 | 11391608 | 240000294 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-08-14 | 1)authoriseddate | 2018-09-01 | 2021-06-21 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005717 | 11791712 | 240000295 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-11-24 | 1)authoriseddate | 2017-12-18 | 2017-11-24 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005718 | 11193132 | 240000296 | CALR | 670 | 1 | 2 | 1 | b:normal,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-09-02 | 1)authoriseddate | 2016-08-18 | 2016-09-02 | null | 0 | null | Fragment length analysis | Cambridge (molecular lab) |
| 240005722 | 11483328 | 240000300 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-12-24 | 1)authoriseddate | 2018-01-19 | 2017-12-24 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005723 | 11223208 | 240000301 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-03-18 | 1)authoriseddate | 2016-07-21 | 2017-03-18 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005724 | 10800084 | 240000302 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-01-01 | 1)authoriseddate | 2017-10-27 | 2018-01-01 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005725 | 10876966 | 240000304 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-09-26 | 1)authoriseddate | 2016-10-22 | 2016-09-26 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005726 | 10569827 | 240000305 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-03-31 | 1)authoriseddate | 2019-04-03 | 2019-03-31 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005727 | 10992657 | 240000308 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-01-07 | 1)authoriseddate | 2017-04-11 | 2018-01-07 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005728 | 11495330 | 240000309 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-08-29 | 1)authoriseddate | 2016-09-08 | 2016-08-29 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005729 | 10699324 | 240000312 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-10-16 | 1)authoriseddate | 2018-11-12 | 2018-10-16 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005730 | 10729929 | 240000313 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-08-17 | 1)authoriseddate | 2016-06-18 | 2016-08-17 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005731 | 10669102 | 240000314 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 1 | c.1142_1144delp.(Glu381del) | c.1142_1144delp.(Glu381del) | 2019-06-27 | 2)requesteddate | 2019-06-28 | 2019-06-27 | p.(Met552_Val555del) | 1 | p.(Met552_Val555del) | Sequencing, Dideoxy/Sanger | Royal Marsden (molecular lab) |
| 240005733 | 11856227 | 240000320 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-07-20 | 1)authoriseddate | 2016-07-21 | 2016-07-20 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005734 | 10131368 | 240000322 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-02-12 | 1)authoriseddate | 2016-03-09 | 2016-02-12 | null | 0 | null | Sequencing, Dideoxy/Sanger | Royal Marsden (molecular lab) |
| 240005735 | 10230045 | 240000323 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2019-06-06 | 1)authoriseddate | 2019-05-27 | 2019-06-06 | null | 0 | null | SSCP | Royal Marsden (molecular lab) |
| 240003694 | 10734233 | 240000846 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-02-06 | 1)authoriseddate | 2016-02-21 | 2016-02-06 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005736 | 10112685 | 240000324 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-03-05 | 2)requesteddate | 2017-02-24 | 2017-03-05 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005737 | 10885375 | 240000325 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 1 | c.1106_1139delp.(Glu369GlyfsTer13) | c.1106_1139delp.(Glu369GlyfsTer13) | 2016-07-06 | 1)authoriseddate | 2016-07-26 | 2016-07-06 | p.(Val560del) | 1 | p.(Val560del) | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005739 | 11591381 | 240000327 | CALR | 670 | 1 | 2 | 1 | a:abnormal,a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-07-04 | 1)authoriseddate | 2017-11-20 | 2018-07-04 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005740 | 11157954 | 240000330 | CALR | 670 | 1 | 1 | 1 | f:not_tested | f:not_tested | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-06-16 | 1)authoriseddate | 2016-02-28 | 2016-06-16 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240003715 | 10451599 | 240000868 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2019-10-21 | 1)authoriseddate | 2019-08-12 | 2019-12-13 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240003728 | 10693143 | 240000883 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2019-03-03 | 1)authoriseddate | 2018-11-29 | 2019-07-30 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005743 | 10382788 | 240000337 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-02-11 | 1)authoriseddate | 2017-06-23 | 2018-02-11 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005745 | 10860732 | 240000339 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-05-13 | 1)authoriseddate | 2019-05-08 | 2019-05-13 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005746 | 10683861 | 240000340 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-07-23 | 1)authoriseddate | 2018-06-23 | 2018-07-23 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005747 | 11995225 | 240000341 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-05-11 | 1)authoriseddate | 2017-06-10 | 2017-05-11 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005748 | 10136502 | 240000343 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-10-12 | 2)requesteddate | 2017-09-19 | 2017-10-12 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005749 | 10642379 | 240000347 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-11-09 | 1)authoriseddate | 2019-07-01 | 2018-12-17 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005750 | 10683406 | 240000350 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-11-19 | 1)authoriseddate | 2019-10-29 | 2020-06-11 | null | 0 | null | Unknown | Royal Marsden (molecular lab) |
| 240003083 | 11324068 | 240000137 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-07-23 | 1)authoriseddate | 2019-08-04 | 2019-07-23 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005661 | 10939687 | 240000183 | CALR | 670 | 1 | 2 | 1 | a:abnormal,a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-08-01 | 1)authoriseddate | 2016-09-29 | 2016-08-01 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005755 | 11696555 | 240000363 | CALR | 670 | 1 | 2 | 1 | b:normal,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-10-20 | 1)authoriseddate | 2016-10-02 | 2016-10-20 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005756 | 10189844 | 240000364 | CALR | 670 | 1 | 2 | 1 | b:normal,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-07-16 | 1)authoriseddate | 2018-08-02 | 2018-07-16 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005757 | 10399754 | 240000365 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-02-06 | 1)authoriseddate | 2018-03-02 | 2018-02-17 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005758 | 11187561 | 240000366 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-08-21 | 1)authoriseddate | 2016-11-08 | 2016-08-21 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005759 | 10863593 | 240000367 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-11-23 | 1)authoriseddate | 2017-12-06 | 2017-11-23 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005760 | 11058154 | 240000369 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-04-09 | 1)authoriseddate | 2018-03-17 | 2018-04-09 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005763 | 11425937 | 240000375 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1154_1155insTTGTC | c.1154_1155insTTGTC | 2018-08-11 | 1)authoriseddate | 2018-09-12 | 2018-08-11 | p.(Asp816Tyr) | 1 | p.(Asp816Tyr) | Fragment length analysis | Royal Marsden (molecular lab) |
| 240003767 | 10452225 | 240000923 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-03-19 | 2)requesteddate | 2016-10-17 | 2017-03-19 | null | 0 | null | Sequencing, Dideoxy/Sanger | Royal Marsden (molecular lab) |
| 240005764 | 10011382 | 240000377 | CALR | 670 | 2 | 3 | 2 | b:normal,b:normal,b:normal | b:normal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-04-14 | 1)authoriseddate | 2016-05-13 | 2016-04-14 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 240005766 | 11924358 | 240000379 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-05-10 | 3)receiveddate | 2019-06-09 | 2019-05-10 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005768 | 10355223 | 240000386 | CALR | 670 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-05-23 | 1)authoriseddate | 2018-06-20 | 2018-05-23 | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005769 | 10551212 | 240000387 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | null | 1)authoriseddate | 2019-06-18 | null | null | 0 | null | Fragment length analysis | Royal Marsden (molecular lab) |
| 240005770 | 10723751 | 240000388 | CALR | 670 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-12-14 | 1)authoriseddate | 2016-12-04 | 2016-12-14 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |