V2 av_gene
255,731 rows · 29 columns
| GENEID | TUMOURID | PATIENTID | GENE_DESC | GENE | COUNT_TESTS | COUNT_RESULTS | COUNT_DATE | ALL_TESTSTATUSES | OVERALL_TS | NO_OF_AB_GATS | DNASEQ_GAT | METHYL_GAT | EXP_GAT | COPYNO_GAT | FUS_TRANS_GAT | ABNORMAL_GAT | NO_OF_SEQ_VARS | ALL_SEQ_VARS | SEQ_VAR | DATE_OVERALL_TS | BEST_DATE_SOURCE_OVERALL_TS | MIN_DATE | MAX_DATE | ALL_PRO_IMPS | NO_OF_PRO_IMPS | PRO_IMP | METHODS | LAB_NAME |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 200009309 | 10489902 | 200003885 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-02-13 | 1)authoriseddate | 2018-03-02 | 2018-02-13 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009310 | 11258331 | 200003886 | BRAF | 6 | 2 | 2 | 2 | b:normal,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-05-31 | 1)authoriseddate | 2017-05-22 | 2017-05-31 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009311 | 10305807 | 200003888 | BRAF | 6 | 1 | 2 | 1 | b:normal,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-07-11 | 1)authoriseddate | 2019-06-04 | 2019-07-11 | null | 0 | null | Sequencing, Next Generation (NGS) | Leeds (molecular lab) |
| 200009312 | 10007512 | 200003890 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1798_1799delinsAA | c.1798_1799delinsAA | 2018-05-06 | 1)authoriseddate | 2018-06-04 | 2018-05-06 | p.(Val600Lys) | 1 | p.(Val600Lys) | Roche COBAS | Royal Marsden (molecular lab) |
| 200009313 | 11499330 | 200003891 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-06-29 | 1)authoriseddate | 2019-06-25 | 2019-06-29 | null | 0 | null | Sequencing, Dideoxy/Sanger | Royal Marsden (molecular lab) |
| 200009314 | 10203160 | 200003893 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-11-09 | 3)receiveddate | 2015-11-17 | 2018-11-09 | null | 0 | null | Pyrosequencing | Birmingham (molecular lab) |
| 200009315 | 11929394 | 200003896 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-10-18 | 1)authoriseddate | 2018-11-06 | 2018-10-18 | null | 0 | null | Pyrosequencing,Roche COBAS | Manchester (molecular lab) |
| 200009316 | 10432600 | 200003897 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-05-23 | 1)authoriseddate | 2016-06-09 | 2016-05-23 | p.V600E | 1 | p.V600E | Roche COBAS | Birmingham (molecular lab) |
| 200009317 | 11814606 | 200003902 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-06-06 | 3)receiveddate | 2018-06-13 | 2018-06-06 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009318 | 10884635 | 200003903 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1798_1799delinsAAp.(Val600Lys) | c.1798_1799delinsAAp.(Val600Lys) | 2016-08-05 | 1)authoriseddate | 2016-08-16 | 2016-08-05 | p.(Val600Lys) | 1 | p.(Val600Lys) | Pyrosequencing | Manchester (molecular lab) |
| 200009319 | 11102818 | 200003904 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 2 | c.1799T>A ,c.1814G>A | multiple | 2018-04-20 | 1)authoriseddate | 2018-04-01 | 2018-04-20 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009320 | 11940577 | 200003905 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-04-23 | 1)authoriseddate | 2016-05-18 | 2016-04-23 | null | 0 | null | Sequencing, Dideoxy/Sanger | Royal Marsden (molecular lab) |
| 200009321 | 10629833 | 200003906 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-09-17 | 1)authoriseddate | 2018-09-13 | 2018-09-17 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009322 | 11781635 | 200003907 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-12-22 | 1)authoriseddate | 2018-11-14 | 2018-12-22 | null | 0 | null | Roche COBAS | Sheffield (molecular lab) |
| 200009323 | 11085684 | 200003908 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-10-19 | 1)authoriseddate | 2018-11-15 | 2018-10-19 | null | 0 | null | Pyrosequencing | Manchester (molecular lab) |
| 200009324 | 10293775 | 200003909 | BRAF | 6 | 1 | 3 | 1 | b:normal,a:abnormal,b:normal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1799T>A | c.1799T>A | 2019-09-18 | 1)authoriseddate | 2019-09-19 | 2019-09-18 | p.Val600Glu | 1 | p.Val600Glu | Roche COBAS | Royal Marsden (molecular lab) |
| 200009325 | 11969977 | 200003910 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-08-18 | 1)authoriseddate | 2016-04-24 | 2016-08-18 | p.V600X | 1 | p.V600X | Unknown | Royal Marsden (molecular lab) |
| 200009326 | 10212676 | 200003911 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2019-12-11 | 1)authoriseddate | 2019-12-12 | 2019-12-11 | p.(Val600Lys) | 1 | p.(Val600Lys) | Sequencing, Dideoxy/Sanger | Newcastle (molecular lab) |
| 200009327 | 10415762 | 200003912 | BRAF | 6 | 1 | 2 | 1 | a:abnormal,c:borderline | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1799T>A | c.1799T>A | 2019-10-29 | 1)authoriseddate | 2019-11-06 | 2019-12-11 | p.(Val600Glu) | 1 | p.(Val600Glu) | Roche COBAS | Royal Marsden (molecular lab) |
| 200009328 | 11930836 | 200003913 | BRAF | 6 | 1 | 2 | 1 | a:abnormal,a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-08-27 | 1)authoriseddate | 2017-08-05 | 2017-08-27 | p.V600X | 1 | p.V600X | Roche COBAS | Royal Marsden (molecular lab) |
| 200009329 | 11732288 | 200003914 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-12-04 | 1)authoriseddate | 2018-01-02 | 2017-12-04 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009333 | 11713225 | 200003918 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-02-16 | 1)authoriseddate | 2018-01-29 | 2018-02-16 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009335 | 11558918 | 200003920 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-12-24 | 1)authoriseddate | 2018-12-16 | 2018-12-24 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009336 | 10344547 | 200003921 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-06-10 | 1)authoriseddate | 2016-11-25 | 2017-06-10 | null | 0 | null | Pyrosequencing | Manchester (molecular lab) |
| 200009337 | 11277822 | 200003922 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1799T>A | c.1799T>A | 2018-09-24 | 1)authoriseddate | 2018-03-16 | 2018-09-24 | p.(Val600Glu) | 1 | p.(Val600Glu) | Sequencing, Next Generation (NGS) | Leeds (molecular lab) |
| 200009338 | 10329230 | 200003924 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-01-06 | 1)authoriseddate | 2019-01-13 | 2019-01-06 | null | 0 | null | Pyrosequencing | Manchester (molecular lab) |
| 200009339 | 10773971 | 200003925 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-03-06 | 1)authoriseddate | 2016-04-05 | 2017-03-06 | null | 0 | null | SSCP | Royal Marsden (molecular lab) |
| 200009340 | 11141251 | 200003926 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-03-27 | 1)authoriseddate | 2019-04-22 | 2019-03-27 | null | 0 | null | Pyrosequencing | Manchester (molecular lab) |
| 200009342 | 10544889 | 200003928 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-12-11 | 3)receiveddate | 2017-11-30 | 2017-12-11 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009343 | 11714451 | 200003929 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1799T>A | c.1799T>A | 2017-06-25 | 3)receiveddate | 2017-07-22 | 2017-06-25 | p.(Val600Glu) | 1 | p.(Val600Glu) | Sequencing, Dideoxy/Sanger | Birmingham (molecular lab) |
| 200009345 | 10277310 | 200003931 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2016-09-12 | 1)authoriseddate | 2016-09-28 | 2016-09-12 | null | 0 | null | Sequencing, Next Generation (NGS) | Royal Marsden (molecular lab) |
| 200009346 | 10129227 | 200003932 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-10-09 | 1)authoriseddate | 2016-09-17 | 2016-10-09 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009347 | 10281890 | 200003933 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-12-26 | 1)authoriseddate | 2017-01-16 | 2016-12-26 | null | 0 | null | SSCP | Royal Marsden (molecular lab) |
| 200009349 | 10393855 | 200003935 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-06-05 | 1)authoriseddate | 2018-07-02 | 2018-06-05 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009350 | 10447173 | 200003936 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-03-28 | 3)receiveddate | 2017-03-09 | 2017-03-28 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009351 | 10675665 | 200003937 | BRAF | 6 | 1 | 2 | 1 | f:not_tested,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-01-30 | 1)authoriseddate | 2019-02-21 | 2019-01-30 | null | 0 | null | Roche COBAS | Royal Marsden (molecular lab) |
| 200009352 | 11846436 | 200003938 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-01-26 | 1)authoriseddate | 2018-02-19 | 2019-03-18 | null | 0 | null | Sequencing, Next Generation (NGS) | Leeds (molecular lab) |
| 200009353 | 11875425 | 200003939 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1798_1799delinsAA | c.1798_1799delinsAA | 2016-12-15 | 1)authoriseddate | 2017-01-11 | 2017-07-06 | p.(Val600Lys) | 1 | p.(Val600Lys) | Roche COBAS | Birmingham (molecular lab) |
| 200009354 | 10132629 | 200003940 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-02-17 | 3)receiveddate | 2018-02-13 | 2018-03-19 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009356 | 11836008 | 200003942 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-10-20 | 1)authoriseddate | 2017-08-23 | 2017-10-20 | null | 0 | null | Pyrosequencing | Manchester (molecular lab) |
| 200009357 | 10211598 | 200003943 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-09-28 | 1)authoriseddate | 2017-09-10 | 2017-09-28 | p.(Thr599dup) | 1 | p.(Thr599dup) | Roche COBAS | Royal Marsden (molecular lab) |
| 200009358 | 10078251 | 200003944 | BRAF | 6 | 1 | 2 | 1 | e:failed,a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2018-05-24 | 1)authoriseddate | 2018-06-06 | 2018-05-24 | p.V600X | 1 | p.V600X | Roche COBAS | Birmingham (molecular lab) |
| 200009359 | 11365828 | 200003945 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-05-12 | 1)authoriseddate | 2017-01-01 | 2017-05-12 | null | 0 | null | Pyrosequencing,Roche COBAS | Manchester (molecular lab) |
| 200009360 | 11108694 | 200003947 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2018-06-14 | 1)authoriseddate | 2018-05-09 | 2018-06-14 | null | 0 | null | Pyrosequencing | Manchester (molecular lab) |
| 200009361 | 10890600 | 200003948 | BRAF | 6 | 1 | 2 | 1 | a:abnormal,b:normal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2019-11-09 | 1)authoriseddate | 2019-10-20 | 2019-11-09 | p.V600R | 1 | p.V600R | Sequencing, Next Generation (NGS) | Leeds (molecular lab) |
| 200009362 | 11807758 | 200003950 | BRAF | 6 | 1 | 2 | 1 | a:abnormal,a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 0 | null | null | 2017-07-25 | 1)authoriseddate | 2017-07-30 | 2017-07-25 | null | 0 | null | Mass Spectrometry Genotyping / MALDI-TOF | Birmingham (molecular lab) |
| 200009363 | 10103144 | 200003951 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2016-08-27 | 1)authoriseddate | 2016-09-21 | 2016-08-27 | null | 0 | null | Roche COBAS | Birmingham (molecular lab) |
| 200009364 | 10583377 | 200003952 | BRAF | 6 | 1 | 2 | 1 | e:failed,b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2017-08-30 | 1)authoriseddate | 2017-08-15 | 2017-08-30 | null | 0 | null | SSCP | Royal Marsden (molecular lab) |
| 200009365 | 10313638 | 200003953 | BRAF | 6 | 1 | 1 | 1 | a:abnormal | a:abnormal | 1 | a:abnormal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | dna_sq | 1 | c.1799T>A | c.1799T>A | 2018-06-23 | 3)receiveddate | 2018-05-21 | 2018-06-23 | null | 0 | null | SSCP | Sheffield (molecular lab) |
| 200009366 | 11335159 | 200003954 | BRAF | 6 | 1 | 1 | 1 | b:normal | b:normal | 0 | b:normal_dna_sq | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | n:not_applicable_null | null | 0 | null | null | 2019-09-01 | 1)authoriseddate | 2019-09-16 | 2019-09-01 | null | 0 | null | Pyrosequencing,Unknown | Nottingham (molecular lab) |