Methodology: OS = time from diagnosis (DIAGNOSISDATEBEST) to death or censoring at last known alive date. TTNT = Time to Next Treatment — time from regimen start to start of next regimen or death. TTNT is a proxy for progression-free survival; no explicit progression dates are available in the Simulacrum. Kaplan-Meier estimates computed using the lifelines library. Minimum 10 patients required per curve.